Pluripotency on Lockdown after Deletion of Three Transcription Regulators.
Identifieur interne : 002885 ( Main/Exploration ); précédent : 002884; suivant : 002886Pluripotency on Lockdown after Deletion of Three Transcription Regulators.
Auteurs : Jennifer A. Mitchell [Canada]Source :
- Cell stem cell [ 1875-9777 ] ; 2019.
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Abstract
Exit from the naive pluripotent state occurs through a series of changes in the gene regulatory circuitry, allowing cells to become primed for lineage commitment. In this issue of Cell Stem Cell, Kalkan et al. (2019) show that three transcription regulators are required for naive mouse embryonic stem cells (ESCs) to exit the pluripotent state.
DOI: 10.1016/j.stem.2019.04.008
PubMed: 31051130
Affiliations:
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